Hybridization capture sequencing to quickly identify canine urinary pathogens and resistance genes
Official title: Hybridization capture-based sequencing as a novel diagnostic for simultaneous identification and AMR profiling of bacterial pathogens causing canine urinary tract infections
Funded at University of Illinois at Urbana-Champaign · NIH-11519326 · Data updated 2026-11-12
A new sequencing approach directly from dog urine aims to rapidly identify bacteria causing urinary infections and their drug-resistance profiles to guide treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $56,122 |
| NIH project number | 1U18FD008925-01 |
| Project ID | NIH-11519326 on NIH RePORTER |
Who could benefit from this research
✓Could help
Dogs presenting with urinary tract infections or urinary symptoms at participating veterinary clinics.
✕Less likely to help
Healthy dogs or dogs without urinary infections may not benefit from this diagnostic approach.
What this research studies
This project tests a probe-based sequencing method that works directly on canine urine samples, without needing to first grow the bacteria. By capturing relevant DNA, the approach could speed up diagnosis and help veterinarians choose effective antibiotics sooner. The study will assess how well this method identifies pathogens and detects antimicrobial resistance genes in real-world urine samples. The results could expandVet-LIRN’s ability to support antimicrobial stewardship in veterinary care.
Why it matters
Potential benefit: If successful, dogs with urinary tract infections could receive quicker and more targeted treatments.
How similar studies have gone: Prior sequencing approaches require culture in many cases, but direct-from-sample capture methods have shown promise in other contexts, with this study extending that concept to canine urine.
Where this research is happening
-
University of Illinois at Urbana-Champaign
Champaign, United States Active
Researchers
- Principal investigator: Wang, Leyi — University of Illinois at Urbana-Champaign
- Study coordinator: Wang, Leyi
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.