Hybrid screening and treatment for cervical cancer using self-collected HPV tests in Mozambique
Official title: A hybrid type III effectiveness-implementation, pragmatic intervention trial for cervical cancer screen and treat in Mozambique
Funded at Tulane University of Louisiana · NIH-11418165 · Data updated 2026-11-12
A pragmatic, real-world trial will test how well a self-collected HPV DNA test followed by treatment works to reduce cervical cancer in women in Mozambique.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $409,136 |
| NIH project number | 5U01CA294674-03 |
| Project ID | NIH-11418165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women aged 25-49 in Mozambique who are eligible for cervical cancer screening and able to provide a self-collected HPV sample.
✕Less likely to help
Women who do not participate in screening or who have no access to subsequent treatment may not benefit.
What this research studies
This project tests a practical approach to cervical cancer screening in a low-resource setting, using self-sampling for HPV testing to improve access. It combines evidence-based screening with immediate treatment when precancers are found, focusing on how to implement this in routine care. The study will measure how well healthcare systems can adopt and sustain the screening-and-treat approach in Mozambique, guided by real-world constraints and local workflows.
Why it matters
Potential benefit: If successful, the approach could lead to earlier detection and treatment of precancerous lesions, reducing cervical cancer deaths in LMICs.
How similar studies have gone: Prior studies suggest self-sampling for HPV testing is feasible and acceptable, with promising early results in similar settings.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Moon, D. Troy — Tulane University of Louisiana
- Study coordinator: Moon, D. Troy
Related research
Other NIH-funded projects on the same topics.
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Community and digital tools to reduce HPV and cervical cancer burden
A nurse or health team will test a community-based, digital strategy to help girls and young women, especially in rural areas, get HPV vaccination and cervical cancer prevention services.
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Community and digital tools to reduce HPV and cervical cancer in women with HIV
A community- and digital-technology program aims to help girls and young women, including those with HIV, get more HPV vaccination and cervical cancer prevention services.
-
mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
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Globally useful predictor for cervical cancer treatment response
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
-
HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
-
Hybrid approach to boost cervical cancer screening in Uganda
A tested, community-driven program helps Ugandan women encourage their peers to get free VIA cervical cancer screening.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.