HPV-related cancers in people living with HIV and factors that affect survival
Project 1: Exploring viral and immunological factors of HPV associated cancers in PLWH and its relation to survival
This project looks at how HPV and immune system changes affect HPV-related cancers in people living with HIV to help improve prevention and treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11414780 on NIH RePORTER |
What this research studies
I am a person living with HIV and this project examines tumors caused by HPV to understand viral and immune features that make cancers more common and harder to treat in people like me. Researchers will analyze tumor tissue and immune cells, compare cancers from people with and without HIV, and connect those lab findings to clinical outcomes including survival. The work will include samples and patients from sub-Saharan Africa and from clinics in the United States to identify patterns across different settings. Results are intended to guide better screening, prevention, and treatment choices and to explore whether immunotherapy could benefit people living with HIV.
Who could benefit from this research
Good fit: People living with HIV who have or are being evaluated for HPV-related cancers (such as anal, cervical, vulvar, penile, or oropharyngeal cancers) are the ideal candidates.
Not a fit: People without HIV or those with cancers not caused by HPV are unlikely to directly benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could lead to better screening, prevention, and treatments — including improved use of immunotherapy — for HPV-related cancers in people living with HIV.
How similar studies have performed: Similar immune and viral profiling approaches and immunotherapy have shown benefit in some HPV-related cancers, but data are limited specifically for people living with HIV, so this work extends promising but incomplete evidence.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Botha, Matthys Hendrik — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Botha, Matthys Hendrik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.