HPV-related anal and cervical disease in people living with HIV
CAMPO consortium: HPV-related anogenital disease in people with HIV
This project compares different tests to find the best way to detect precancerous anal and cervical lesions and studies how the anal microbiome relates to HPV in Hispanic people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11378604 on NIH RePORTER |
What this research studies
You would be part of work that looks for the best ways to find high-grade precancerous changes in the anus and cervix among people living with HIV. One part compares test results such as cytology (cell samples), HPV typing, and DNA methylation, alone and combined, to see which catches disease best. Another part studies the bacteria living in the anus to see how differences in the microbiome relate to high-risk HPV and anal disease across Hispanic participants in California, Mexico, and Puerto Rico. The consortium also builds local research capacity so clinics in these regions can better screen and follow people at risk.
Who could benefit from this research
Good fit: Ideal candidates are people living with HIV (including women and men who have sex with men), especially Hispanic participants in California, Mexico, or Puerto Rico, who are willing to provide samples and medical information for HPV and microbiome testing.
Not a fit: People without HIV or those who are not in the enrolled geographic populations (California, Mexico, Puerto Rico) may not be eligible to participate or see direct benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could lead to more accurate and earlier detection of precancerous anal and cervical lesions for people living with HIV.
How similar studies have performed: Cervical screening with cytology and HPV testing has reduced cancer risk, but combining methylation markers and microbiome analysis for anal HPV-related disease is newer and less proven.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Palefsky, Joel Michael — University of California, San Francisco
- Study coordinator: Palefsky, Joel Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.