How zinc levels affect the immune response to pneumonia
Defective Zn Homeostasis impairs host defense against pneumococcal pneumonia
This study is looking at how zinc affects the immune system's ability to fight off pneumococcal pneumonia, a serious lung infection, especially for people who might not be getting enough zinc in their diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10980535 on NIH RePORTER |
What this research studies
This research investigates the role of zinc in the immune response to pneumococcal pneumonia, a common and serious lung infection. It focuses on how zinc transporters, particularly ZIP8, influence the activation of immune cells like macrophages and dendritic cells. By studying the effects of zinc deficiency and supplementation, the research aims to understand how these factors contribute to the body's ability to fight off pneumonia. Patients with low zinc levels may be more susceptible to infections, and this research could lead to improved dietary recommendations and treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with low dietary zinc intake or those at risk for zinc deficiency, especially the elderly or those with compromised immune systems.
Not a fit: Patients who have adequate zinc levels and do not suffer from immune dysfunction related to zinc may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and treatments for pneumonia, particularly in vulnerable populations.
How similar studies have performed: Previous research has shown that zinc supplementation can reduce the incidence of pneumonia, indicating that this approach has potential for success.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Knoell, Daren Lee — University of Nebraska Medical Center
- Study coordinator: Knoell, Daren Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.