How white blood cells organize surface proteins that control inflammation
Endocytic dynamics and surface emergent property of leukocyte Integrins
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11146569
This project looks at how white blood cells arrange surface proteins that help them stick and move, which could help people with autoimmune and inflammatory conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11146569 on ClinicalTrials.gov |
What this research studies
If you have an autoimmune condition, this research explores how immune cells (white blood cells) organize surface proteins called integrins and CD81 that control sticking and movement. Scientists will use unbiased proteomics to find which membrane proteins are carried by an endocytic pathway driven by F-BAR proteins like FBP17 and CIP4. They will test membrane shape and tension effects using engineered systems such as nanobar-supported lipid bilayers and lab experiments to see how curvature influences protein sorting. The goal is to link these cellular patterns to immune cell polarity and migration that matter in inflammation.
Who could benefit from this research
Good fit: Ideal candidates would be people with autoimmune or inflammatory conditions willing to donate blood samples, along with healthy volunteers for comparison.
Not a fit: Patients seeking immediate treatment changes or those without immune or inflammatory conditions are unlikely to see direct, short-term benefits from this laboratory-focused research.
Why it matters
Potential benefit: If successful, findings could point to new targets to reduce harmful immune cell migration and inflammation in autoimmune diseases.
How similar studies have performed: Researchers have used proteomics and synthetic membrane systems successfully before, but applying F-BAR curvature sensing to leukocyte integrin sorting is a relatively new idea.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, MIN — YALE UNIVERSITY
- Study coordinator: WU, MIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases