How weight loss affects heart disease and inflammation
Mechanisms underlying caloric restriction-mediated resolution of atherosclerosis
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-11164995
This study is looking at how eating less and losing weight might help clear up artery blockages, which can improve heart health, and it’s designed for anyone interested in better ways to treat heart conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11164995 on ClinicalTrials.gov |
What this research studies
This research investigates how caloric restriction and weight loss can lead to the resolution of atherosclerosis, a condition characterized by the buildup of plaques in the arteries. By studying the effects of caloric restriction on fat tissue and blood cells, the researchers aim to understand the biological mechanisms that promote healing in the cardiovascular system. The study involves both animal models and potential applications for human health, focusing on how these processes can be harnessed for better treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and at risk for cardiovascular diseases, particularly those with atherosclerosis.
Not a fit: Patients who are not overweight or do not have atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating atherosclerosis and improving cardiovascular health through weight management.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between weight loss and cardiovascular health, indicating that this approach has potential for success.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEINSTOCK, ADA — UNIVERSITY OF CHICAGO
- Study coordinator: WEINSTOCK, ADA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease