How weight loss affects heart disease and inflammation
Mechanisms underlying caloric restriction-mediated resolution of atherosclerosis
This study is looking at how eating less and losing weight might help improve heart health for people with atherosclerosis, which is when plaque builds up in the arteries, and it aims to show how these changes can help heal the heart.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10898714 on NIH RePORTER |
What this research studies
This research investigates how caloric restriction and weight loss can help resolve atherosclerosis, a condition characterized by the buildup of plaques in the arteries. By studying the effects of caloric restriction on fat tissue and blood cells, the researchers aim to understand the biological signals that promote the healing of cardiovascular disease. The study will involve examining changes in atherosclerotic lesions and exploring whether beneficial effects can be transferred through cell transplantation. Patients may gain insights into how weight management can influence heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and have been diagnosed with atherosclerosis or related cardiovascular conditions.
Not a fit: Patients who are not overweight or do not have atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating atherosclerosis and improving cardiovascular health through weight loss.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between weight loss and cardiovascular health, suggesting that this approach may yield significant insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Weinstock, Ada — University of Chicago
- Study coordinator: Weinstock, Ada
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.