How VCAM1 affects bone marrow stem cells
Official title: REGULATION OF BONE MARROW MESENCHYMAL STEM CELLS BY VCAM1
Funded at University of Illinois at Chicago · NIH-10987020 · Data updated 2026-11-12
This study is looking at how a specific protein called VCAM1 helps support important stem cells in the bone marrow, which could lead to new ways to improve treatments for blood-related conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $42,693 |
| NIH project number | 5F31HL165859-03 |
| Project ID | NIH-10987020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may have conditions affecting blood cell formation or bone marrow function.
✕Less likely to help
Patients with conditions unrelated to bone marrow or blood cell production may not receive any benefit from this research.
What this research studies
This research investigates the role of Vascular Cell Adhesion Molecule-1 (VCAM1) in regulating bone marrow mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs). It focuses on understanding how MSCs, which are crucial for maintaining the bone marrow environment, utilize VCAM1 to support the function and maintenance of HSCs. The study employs various assays to analyze the interactions between these cells and the factors that influence their behavior in the bone marrow niche. By exploring these mechanisms, the research aims to uncover new insights into stem cell biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing blood cell production and treating blood-related disorders.
How similar studies have gone: Previous research has shown that targeting adhesion molecules like VCAM1 can influence stem cell behavior, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Di Staulo, Anna Marisa — University of Illinois at Chicago
- Study coordinator: Di Staulo, Anna Marisa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.