How UVB light causes skin cancer through specific molecular mechanisms
Official title: Molecular mechanisms of cNOS-mediated NF-kappa B activation in regulation of ultraviolet B light-induced photocarcinogenic responses
Funded at Ohio University Athens · NIH-10613450 · Data updated 2026-11-12
This study is looking at how UVB light from the sun can lead to skin cancer by affecting skin cells, especially focusing on a protein that might help damage DNA and keep unhealthy cells alive, with the hope of finding new ways to prevent skin cancer for everyone who enjoys being outdoors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | July 1, 2019 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $339,750 |
| NIH project number | 5R01ES030425-05 |
| Project ID | NIH-10613450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk for skin cancer, particularly those with significant UV exposure or a history of skin lesions.
✕Less likely to help
Patients who have already been diagnosed with advanced skin cancer may not benefit directly from this research.
What this research studies
This research investigates how ultraviolet B (UVB) light contributes to skin cancer by activating certain molecular pathways in skin cells. It focuses on the role of a protein called constitutive nitric oxide synthase (cNOS) in promoting DNA damage and preventing cell death, which can lead to cancer development. The researchers aim to understand the detailed mechanisms behind this process, which could help in developing new treatments to prevent skin cancer caused by UVB exposure.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent skin cancer by targeting specific molecular pathways activated by UVB light.
How similar studies have gone: Previous research has shown promising results in targeting molecular pathways related to skin cancer, indicating that this approach could be effective.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Wu, Shiyong — Ohio University Athens
- Study coordinator: Wu, Shiyong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.