How two blood-vessel signals control leakiness in inflamed lungs
Crosstalk between S1P Receptor 1/S1P1 and P-Selectin/Selp in Regulation of Inflammatory Vascular Permeability
Finding out whether targeting the S1P1 and P-selectin pathways can reduce dangerous blood vessel leak in people with ARDS or severe lung injury.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11193841 on NIH RePORTER |
What this research studies
This project looks at two signals in blood vessels—S1P1 and P-selectin—that help control how leaky lung blood vessels become during severe inflammation. Researchers will test drugs that mimic S1P (such as TySIPonate) to tighten vessel barriers and study how S1PR3 and other markers in blood relate to lung injury. The team combines lab work in cells and animal models with analysis of human genetic markers and patient-derived blood samples to connect molecular findings to people with ARDS. The overall aim is to identify treatments and blood tests that could guide care for patients with acute lung injury.
Who could benefit from this research
Good fit: Adults with acute respiratory distress syndrome (ARDS), severe acute lung injury, or ventilator-induced lung injury—including cases related to COVID-19—are the most likely candidates for participation.
Not a fit: People with mild, chronic stable lung conditions or forms of respiratory disease that are not driven by vascular leak are unlikely to benefit directly from this work.
Why it matters
Potential benefit: Could lead to treatments that prevent or reverse life-threatening lung blood-vessel leak and improve survival and recovery in ARDS.
How similar studies have performed: Preclinical studies in animals and cells have shown that S1P and S1P1-targeting compounds can reduce vascular leak, but human clinical benefit has not yet been established.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Dudek, Steven M — University of Florida
- Study coordinator: Dudek, Steven M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.