How trophoblast cells help regulate the immune system during pregnancy
Mechanisms of trophoblast-induced immune modulation
This study is looking at how special cells in the placenta help protect both mom and baby from infections during pregnancy, and it aims to find ways to boost this natural defense for healthier pregnancies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10671640 on NIH RePORTER |
What this research studies
This research investigates the role of trophoblast cells, which are the first cells to interact with the mother's immune system during pregnancy. It focuses on how these cells use specific receptors to detect infections and respond to them, particularly looking at the signaling pathways involved in protecting both the mother and fetus from viral infections. By understanding these mechanisms, the research aims to uncover how the immune response can be modulated to ensure a healthy pregnancy. The study employs various experimental models, including genetically modified mice, to explore these interactions in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals, particularly those at risk for viral infections.
Not a fit: Patients who are not pregnant or those with no history of viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing viral infections during pregnancy, enhancing maternal and fetal health.
How similar studies have performed: Previous research has shown that understanding immune mechanisms at the maternal-fetal interface can lead to significant advancements in maternal and fetal health, indicating a promising avenue for this study.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Mor, Gil G — Wayne State University
- Study coordinator: Mor, Gil G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.