How triglycerides and diabetes affect heart disease risk
Triglycerides, Diabetes and Cardiovascular Disease
['FUNDING_P01'] · UNIVERSITY OF WASHINGTON · NIH-10874513
This study is looking at how certain proteins affect fat metabolism in people with diabetes, even when their fat levels seem normal, to help find ways to prevent heart problems related to diabetes.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10874513 on ClinicalTrials.gov |
What this research studies
This research investigates how certain proteins influence the metabolism of triglyceride-rich lipoproteins in patients with diabetes, even when their triglyceride levels appear normal. By understanding the role of these proteins, the study aims to uncover how they contribute to the accumulation of harmful lipoprotein particles that increase the risk of cardiovascular disease. The research employs advanced analytical tools and focuses on specific pathways to better understand the mechanisms behind atherosclerosis and cardiovascular complications in diabetic patients. The goal is to identify potential prevention and treatment strategies for cardiovascular disease linked to diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with diabetes, particularly those experiencing cardiovascular complications or at risk for heart disease.
Not a fit: Patients without diabetes or those who do not have cardiovascular disease risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cardiovascular disease in patients with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of triglyceride metabolism in cardiovascular disease, suggesting that this approach could yield significant insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BORNFELDT, KARIN E. — UNIVERSITY OF WASHINGTON
- Study coordinator: BORNFELDT, KARIN E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Atherosclerotic Cardiovascular Disease, Brittle Diabetes Mellitus, Cardiovascular Diseases