How the protein EEPD1 helps cells fix dangerous DNA damage during copying
EEPD1 Repair of Stressed Replication Forks
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11249660
This research finds out whether the protein EEPD1 helps cells repair DNA damage that can cause cancer or harm aging tissues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11249660 on ClinicalTrials.gov |
What this research studies
From a patient perspective, researchers are studying a protein called EEPD1 that may step in when DNA is damaged while cells copy their DNA. They will use laboratory cell experiments and genetic methods to compare EEPD1’s activity to the known repair enzyme APE1 and test what happens when EEPD1 is reduced or removed. The team will measure how well damaged DNA forks are repaired, how cells restart replication, and how cell survival is affected after oxidative stress. Results may use cell models and in vivo systems to show whether EEPD1 can protect cells from collapse of replication forks.
Who could benefit from this research
Good fit: People with cancers linked to DNA-repair problems or patients willing to donate tumor or tissue samples could be most relevant to this line of research.
Not a fit: Patients seeking immediate clinical treatments or symptom relief are unlikely to benefit directly because this is laboratory-focused basic research.
Why it matters
Potential benefit: If successful, this work could point to new targets or strategies to protect tissues from DNA damage and to develop therapies for cancers with DNA repair defects.
How similar studies have performed: Previous laboratory studies indicate EEPD1 can perform repair activities similar to APE1 and help restart damaged replication forks, but translating this into patient therapies remains unproven.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HROMAS, ROBERT A — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: HROMAS, ROBERT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Brain Cancer