How the metabolic clock influences cell survival and growth
Official title: The metabolic clock as a regulator of cell fate decision
Funded at Ohio State University · NIH-10941105 · Data updated 2026-11-12
This study looks at how the body's internal clock influences B cells, which are important for our immune system, in deciding whether to grow or die, with the goal of finding new ways to help treat diseases like autoimmune disorders and cancers that happen when these decisions go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $372,588 |
| NIH project number | 1R35GM155038-01 |
| Project ID | NIH-10941105 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or cancers that involve B cell dysfunction.
✕Less likely to help
Patients with conditions unrelated to B cell function or those not experiencing issues with cell fate decisions may not benefit from this research.
What this research studies
This research investigates how the body's metabolic clock affects the decisions cells make regarding their survival and proliferation. It focuses on B cells, which are crucial for immune responses, and examines how different signals can either promote their growth or lead to cell death. By understanding these mechanisms, the research aims to uncover the underlying causes of various diseases, including autoimmune disorders and cancers, that arise from improper cell fate decisions. The approach combines insights from cell signaling, metabolism, and the immune system to explore potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases and cancers by improving our understanding of how to regulate cell survival and proliferation.
How similar studies have gone: Previous research has shown promising results in understanding cell fate decisions, but this specific approach focusing on the metabolic clock is relatively novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Akkaya, Munir — Ohio State University
- Study coordinator: Akkaya, Munir
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.