How the LPGAT1 enzyme affects liver fat and blood lipids
The Function of Mammalian LPGAT1
This project looks at how the LPGAT1 enzyme in liver cells changes fat molecules and influences blood lipids for people with high cholesterol, fatty liver, or related heart disease risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11262282 on NIH RePORTER |
What this research studies
Researchers will study the LPGAT1 enzyme using purified protein and lab tests to define the exact chemical reaction it carries out on phospholipids. They will change LPGAT1 activity in liver cell models to see how that alters the placement of saturated fats in membrane lipids and how those changes affect new fat synthesis. The team will measure effects on lipoprotein production that contribute to blood cholesterol and atherosclerosis. Findings will map a previously unclear pathway that could point to ways to alter harmful blood lipids.
Who could benefit from this research
Good fit: Adults with high cholesterol, fatty liver disease, metabolic syndrome, or atherosclerotic cardiovascular disease could be relevant for donating samples or joining follow-on studies or clinical trials.
Not a fit: People without lipid-related or metabolic conditions are unlikely to gain direct benefit from this lab-based research.
Why it matters
Potential benefit: If successful, this work could identify a new target for changing blood lipid composition and lowering risk of atherosclerotic cardiovascular disease.
How similar studies have performed: Related work on phospholipid remodeling and lipid enzymes has informed lipid biology, but targeting LPGAT1 is a relatively new approach with limited prior clinical testing.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Schlame, Michael — New York University School of Medicine
- Study coordinator: Schlame, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.