How the inflammasome affects gut health and glucose levels
The Inflammasome in the Regulation of Intestinal Glucose Homeostasis, Microbiota and Inflammation
This study is looking at how a protein called the inflammasome affects gut health, inflammation, and blood sugar levels, especially for people with inflammatory bowel diseases like ulcerative colitis and Crohn's disease, by examining mice to see how genetics, gut bacteria, and diet play a role.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10848322 on NIH RePORTER |
What this research studies
This research investigates the role of the inflammasome, a protein complex, in regulating gut health, inflammation, and glucose levels in the intestines. It aims to understand how genetic factors, gut bacteria, and diet contribute to inflammatory bowel diseases (IBD) like ulcerative colitis and Crohn's disease. By studying mice with deficiencies in the inflammasome, researchers will explore how this signaling pathway influences the gut microbiome and glucose metabolism. The findings could lead to new insights into maintaining intestinal health and preventing IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with inflammatory bowel diseases such as ulcerative colitis or Crohn's disease.
Not a fit: Patients without inflammatory bowel diseases or those with unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for inflammatory bowel diseases and improve glucose metabolism in affected patients.
How similar studies have performed: Previous research has shown that targeting the inflammasome can influence gut health and inflammation, suggesting potential for success in this area.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Zaki, Hasan — Ut Southwestern Medical Center
- Study coordinator: Zaki, Hasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.