How the immune system's metabolism affects viral and bacterial infections
Official title: Regulation of viral-bacterial co-infections by immunometabolism
Funded at Dartmouth College · NIH-10880932 · Data updated 2026-11-12
This study is looking at how changes in the immune system affect the way viral and bacterial infections work together in people with Cystic Fibrosis, especially focusing on a tough lung infection called Pseudomonas aeruginosa, to find new ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $674,449 |
| NIH project number | 1R01HL169973-01A1 |
| Project ID | NIH-10880932 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Cystic Fibrosis who experience respiratory infections, particularly those with a history of viral infections.
✕Less likely to help
Patients without Cystic Fibrosis or those not experiencing respiratory infections may not benefit from this research.
What this research studies
This research investigates how the immune system's metabolic changes influence the interaction between viral and bacterial infections, particularly in patients with Cystic Fibrosis (CF). It focuses on the respiratory pathogen Pseudomonas aeruginosa, which can become resistant to antibiotics when it forms biofilms in the lungs. The study aims to understand how viral infections can lead to chronic bacterial infections by examining the immune response and metabolic processes involved. By analyzing these interactions, the research seeks to identify potential therapeutic targets to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in CF patients, potentially reducing lung damage and improving their quality of life.
How similar studies have gone: Previous research has shown that understanding the immune response to infections can lead to significant advancements in treatment strategies, suggesting that this approach has the potential for success.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Bomberger, Jennifer Melinda — Dartmouth College
- Study coordinator: Bomberger, Jennifer Melinda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.