How the immune system affects kidney function and blood pressure in women with autoimmune disease
Official title: Innate Immune Mediated Changes in Renal Function to Cause Hypertension in Females with Autoimmune Disease
Funded at Augusta University · NIH-10918132 · Data updated 2026-11-12
This study is looking at how the immune system affects kidney health and blood pressure in women with autoimmune diseases like lupus, to find new ways to help manage high blood pressure in these patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $312,598 |
| NIH project number | 5U54HL169191-02 |
| Project ID | NIH-10918132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with systemic lupus erythematosus or other autoimmune diseases who are experiencing hypertension.
✕Less likely to help
Patients without autoimmune diseases or those not experiencing hypertension may not benefit from this research.
What this research studies
This research investigates the relationship between the immune system and kidney function in women suffering from autoimmune diseases, particularly systemic lupus erythematosus (SLE). It aims to understand how immune responses contribute to hypertension by examining the mechanisms that lead to kidney damage and increased blood pressure. The study will utilize experimental models to explore how certain immune cells and signals affect kidney health and function. By identifying these pathways, the research hopes to uncover potential therapeutic targets for managing hypertension in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension in women with autoimmune diseases, improving their overall health and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the immune mechanisms involved in hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Ryan, Michael — Augusta University
- Study coordinator: Ryan, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.