How the immune system affects heart function
Official title: Impact of Adaptive Immune System on Cardiac Electrophysiology
Funded at Ohio State University · NIH-11133271 · Data updated 2026-11-12
This study is looking at how certain immune cells called CD4+ T-cells might affect heart problems like heart failure and irregular heartbeats after a heart attack, with the hope of finding new ways to help treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 5, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $741,112 |
| NIH project number | 1R01HL174473-01A1 |
| Project ID | NIH-11133271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced heart conditions such as myocardial infarction or heart failure.
✕Less likely to help
Patients with heart conditions unrelated to immune system involvement may not benefit from this research.
What this research studies
This research investigates the role of the adaptive immune system, specifically CD4+ T-cells, in heart diseases such as heart failure and arrhythmias. It aims to understand how these immune cells contribute to cardiac dysfunction after events like myocardial infarction. By studying the interactions between activated T-cells and heart cells, the research seeks to uncover mechanisms that lead to heart problems, potentially paving the way for new treatment strategies. The approach includes using animal models to observe the effects of T-cell transfer on heart function and structure.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce complications for patients with heart disease.
How similar studies have gone: Previous research has shown that immune system interactions can significantly impact heart health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Deschenes, Isabelle — Ohio State University
- Study coordinator: Deschenes, Isabelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.