How the immune system affects eye diseases
Official title: Antigen presentation to the adaptive immune system in the choroid contributes to ocular autoimmune disease
Funded at Washington University · NIH-10911300 · Data updated 2026-11-12
This study is looking into how the immune system affects eye autoimmune diseases, especially how certain cells in the eye help trigger these conditions, with the goal of finding better ways to treat and care for people who have these eye issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $240,262 |
| NIH project number | 5K08EY034601-02 |
| Project ID | NIH-10911300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ocular autoimmune diseases, such as anterior uveitis.
✕Less likely to help
Patients with non-autoimmune eye conditions or those not affected by ocular diseases may not benefit from this research.
What this research studies
This research investigates the role of the adaptive immune system in ocular autoimmune diseases, particularly focusing on how antigen presentation in the choroid contributes to these conditions. The principal investigator, with a background in neuroscience and ophthalmology, aims to develop new experimental models and research questions that will enhance understanding of eye-related autoimmune processes. Through a combination of training and mentorship, the project seeks to advance knowledge in ocular immunology, ultimately leading to improved patient care and treatment options for those affected by these diseases.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with ocular autoimmune diseases.
How similar studies have gone: Previous research in the field of ocular autoimmunity has shown promising results, indicating that understanding immune mechanisms can lead to significant advancements in treatment.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Walsh, James — Washington University
- Study coordinator: Walsh, James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.