How the brain’s angiotensin system controls blood pressure and metabolism
Official title: Cellular and Molecular Mechanisms of Cardiometabolic Control by Angiotensin in the Brain: Role of AT1 Receptors and Biased Signaling
Funded at Medical College of Wisconsin · NIH-11420072 · Data updated 2026-11-12
A research program will explore how brain angiotensin signaling, especially AT1 receptors, influences blood pressure and metabolic regulation in adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $2,753,400 |
| NIH project number | 1P01HL180287-01A1 |
| Project ID | NIH-11420072 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for hypertension or metabolic disorders may be relevant for future translational applications.
✕Less likely to help
Individuals without cardiovascular or metabolic conditions may not directly benefit from this research.
What this research studies
This project investigates the brain circuits and signaling pathways that link angiotensin to blood pressure, fluid balance, and energy use in adults. It focuses on how AT1 receptors and biased signaling in neural networks affect hypertension and obesity risk, including how these mechanisms might be altered by early-life factors. The team uses a systems and molecular approach to map neural connections and test signaling outcomes that control neurohumoral and metabolic regulation. Outcomes could reveal targets to modulate brain pathways that influence BP and metabolism. Overall, the work aims to translate basic brain biology into ideas for better treatment of high blood pressure and metabolic disorders.
Why it matters
Potential benefit: If successful, the research could identify brain targets to better manage blood pressure and metabolic health in adults.
How similar studies have gone: Previous work in brain angiotensin systems has shown meaningful links to BP and metabolism, suggesting potential for impactful findings with this approach.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Sigmund, Curt Daniel — Medical College of Wisconsin
- Study coordinator: Sigmund, Curt Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.