How the brain controls kidney function
Official title: Autonomic control of kidney function
Funded at Beth Israel Deaconess Medical Center · NIH-11092691 · Data updated 2026-11-12
This study is looking at how certain brain cells help control kidney function, especially when the kidneys are injured, to find new ways to improve kidney health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 15, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $650,777 |
| NIH project number | 5R01DK135541-03 |
| Project ID | NIH-11092691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing acute kidney injury or those at risk for kidney-related complications.
✕Less likely to help
Patients with chronic kidney disease unrelated to acute injury may not benefit from this research.
What this research studies
This research investigates how specific brain neurons regulate kidney function, particularly during acute kidney injury. By examining the connections between the hypothalamus and spinal cord, researchers aim to understand how these neurons influence kidney processes such as salt balance and blood flow. The study employs advanced techniques like RNA sequencing to identify and characterize the neuron populations involved in renal control. This could lead to new insights into managing kidney-related health issues.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for acute kidney injury and related conditions.
How similar studies have gone: Other research has shown promising results in understanding brain-kidney interactions, suggesting potential for breakthroughs in this area.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Zeidel, Mark L. — Beth Israel Deaconess Medical Center
- Study coordinator: Zeidel, Mark L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.