How T cells behave in type 1 diabetes
Official title: Transcriptional control of T cell function during type 1 diabetes
Funded at National Jewish Health · NIH-10995292 · Data updated 2026-11-12
This study is looking at how T cells, which help your immune system, behave in people with type 1 diabetes to find ways to protect the insulin-producing cells in the pancreas from being harmed.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $114,626 |
| NIH project number | 5K01DK134835-02 |
| Project ID | NIH-10995292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who have active autoimmune responses.
✕Less likely to help
Patients with type 2 diabetes or other non-autoimmune related conditions may not benefit from this research.
What this research studies
This research investigates how T cells, which are crucial for immune responses, function in patients with type 1 diabetes. It focuses on understanding the transcriptional programs that control T cell behavior when they encounter self-antigens, which are proteins from the body that can trigger autoimmune responses. By studying these mechanisms, the research aims to identify ways to modulate T cell activity to potentially reduce the damage to insulin-producing cells in the pancreas. The approach includes analyzing gene expression patterns in T cells from diabetic models to uncover targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve insulin-producing cells in patients with type 1 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding T cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Shaw, Laura — National Jewish Health
- Study coordinator: Shaw, Laura
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.