How T cells behave in type 1 diabetes
Transcriptional control of T cell function during type 1 diabetes
This study is looking at how T cells, which help your immune system, behave in people with type 1 diabetes to find ways to protect the insulin-producing cells in the pancreas from being harmed.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10995292 on NIH RePORTER |
What this research studies
This research investigates how T cells, which are crucial for immune responses, function in patients with type 1 diabetes. It focuses on understanding the transcriptional programs that control T cell behavior when they encounter self-antigens, which are proteins from the body that can trigger autoimmune responses. By studying these mechanisms, the research aims to identify ways to modulate T cell activity to potentially reduce the damage to insulin-producing cells in the pancreas. The approach includes analyzing gene expression patterns in T cells from diabetic models to uncover targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who have active autoimmune responses.
Not a fit: Patients with type 2 diabetes or other non-autoimmune related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve insulin-producing cells in patients with type 1 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding T cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Shaw, Laura — National Jewish Health
- Study coordinator: Shaw, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.