How T-cell receptors sense mechanical forces to recognize antigens
Biology and structure of pMHC receptors functioning as mechanosensors in the [alpha][beta] T-cell lineage
This study is exploring how T-cells, which are important for our immune system, sense physical forces to tell the difference between our own cells and harmful ones, like infections or cancer, and the findings could help develop new treatments for autoimmune diseases and cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10877939 on NIH RePORTER |
What this research studies
This research investigates how T-cell receptors (TCRs) on T lymphocytes detect mechanical forces to distinguish between self and non-self antigens presented by other cells. By using advanced techniques like optical tweezers, the study aims to understand the biophysical properties that influence TCR activation and thymocyte development. The goal is to uncover the mechanisms behind T-cell responses to infections and cancer, which could lead to new therapeutic strategies. Patients may benefit from insights gained about T-cell function in autoimmune diseases and cancer.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with autoimmune diseases or cancers that involve T-cell responses.
Not a fit: Patients with conditions unrelated to T-cell function or those not involving immune responses may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and cancer by enhancing our understanding of T-cell activation.
How similar studies have performed: Other research has shown promising results in understanding T-cell mechanics, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Reinherz, Ellis L — Dana-Farber Cancer Inst
- Study coordinator: Reinherz, Ellis L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.