How syndecan-1 helps reduce lung inflammation
Syndecan-1 suppression of lung inflammation
This study is looking at how a protein called syndecan-1 helps reduce lung inflammation in people with acute respiratory distress syndrome (ARDS) by helping clear out dying lung cells, with the hope of finding new ways to improve recovery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11065447 on NIH RePORTER |
What this research studies
This research investigates the role of syndecan-1 in managing lung inflammation, particularly in patients suffering from acute respiratory distress syndrome (ARDS). It focuses on how syndecan-1 aids in the clearance of dying lung cells, which is crucial for resolving inflammation after lung injuries. By understanding the mechanisms of cell death and clearance, the research aims to identify new therapeutic strategies to improve patient outcomes in ARDS. The study employs various biological assays and models to explore these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome or related lung conditions.
Not a fit: Patients with chronic lung diseases or those not experiencing acute respiratory distress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce lung inflammation and improve recovery for patients with ARDS.
How similar studies have performed: Previous research has shown promising results in targeting apoptosis and inflammation in lung conditions, suggesting that this approach may yield significant advancements.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Chen, Peter — Cedars-Sinai Medical Center
- Study coordinator: Chen, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.