How substance P affects bone damage from staph infections
Official title: Substance P exacerbation of staphylococcal bone damage
Funded at University of North Carolina Charlotte · NIH-10872180 · Data updated 2026-11-12
This study is looking at how a substance called substance P might make inflammation and bone damage worse in people with staph infections, especially in cases of osteomyelitis, to help us understand how it affects bone health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project start | September 19, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $382,474 |
| NIH project number | 5R01AI170012-03 |
| Project ID | NIH-10872180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from osteomyelitis or other bone infections caused by Staphylococcus aureus.
✕Less likely to help
Patients with bone infections caused by other bacteria or those without significant inflammation may not benefit from this research.
What this research studies
This research investigates the role of substance P, a neuropeptide, in worsening inflammation and bone damage caused by staphylococcal infections, particularly osteomyelitis. The study will evaluate how substance P interacts with bone cells and contributes to the dysregulation of bone remodeling and destruction. Using both isolated human and murine bone cells, as well as established animal models, the research aims to understand the mechanisms by which substance P exacerbates inflammation in infected bone tissue.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to mitigate bone damage and inflammation in patients with staphylococcal infections.
How similar studies have gone: Previous research has shown that targeting neuropeptides can influence inflammation, suggesting potential success for this approach in treating bone infections.
Where this research is happening
-
University of North Carolina Charlotte
Charlotte, United States Active
Researchers
- Principal investigator: Marriott, Ian — University of North Carolina Charlotte
- Study coordinator: Marriott, Ian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.