How stress responses interact with the body's internal clock
Integrated stress response and the circadian clock
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11099182
This study is looking at how our body's internal clock and stress response work together, and how problems with this balance might affect brain health, using mice to help understand these connections better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11099182 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the integrated stress response (ISR) and the circadian clock, two essential processes that regulate how neurons function. By studying how these systems communicate, the research aims to uncover how disruptions in circadian rhythms can lead to various health issues. The team will use advanced mouse models and a mix of molecular, cellular, and behavioral techniques to explore these interactions and their implications for neuronal health and function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing neurological issues related to circadian rhythm disturbances.
Not a fit: Patients with stable neurological conditions that do not involve circadian rhythm disruptions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating brain disorders linked to circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in understanding the links between stress responses and circadian rhythms, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAO, RUIFENG (RAY) — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: CAO, RUIFENG (RAY)
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Diseases, Brain Disorders