How stress in intestinal cells changes Salmonella gut infections
The impact of ER stress on Salmonella Typhimurium infections
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11373347
Researchers are looking at whether stress inside gut cells changes how Salmonella causes intestinal infection and inflammation for people with bacterial gastroenteritis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11373347 on ClinicalTrials.gov |
What this research studies
This project looks inside intestinal cells to see how endoplasmic reticulum (ER) stress and the unfolded protein response change immune signals during Salmonella Typhimurium infection. Scientists will focus on key molecules such as ATF6, IRE1α, PERK and the NOD1/NOD2 sensors to learn how they affect inflammation and bacterial survival. Work will use lab-grown intestinal cells and infection models, plus tissue-based experiments, to measure cell signaling, cell death, and bacterial control when ER stress pathways are altered. The goal is to connect laboratory findings to intestinal inflammation seen during bacterial gut infections.
Who could benefit from this research
Good fit: Ideal candidates would be people who have had recent Salmonella Typhimurium gut infections or ongoing intestinal inflammation linked to bacterial infection.
Not a fit: People whose symptoms are caused by viruses, non-infectious digestive disorders, or unrelated conditions are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could point to new ways to reduce gut inflammation or improve defenses against Salmonella infections.
How similar studies have performed: Previous laboratory studies have connected ER stress and NOD1/NOD2 signaling to intestinal inflammation, but applying these findings specifically to Salmonella infection is a newer direction.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KEESTRA-GOUNDER, ARINA MARIJKE — UNIVERSITY OF COLORADO DENVER
- Study coordinator: KEESTRA-GOUNDER, ARINA MARIJKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections