How stress in cells affects infections from Salmonella bacteria
The impact of ER stress on Salmonella Typhimurium infections
This study is looking at how stress in our cells affects how our body fights off infections from Salmonella, focusing on certain receptors that help trigger inflammation, and it hopes to find new ways to better manage gut infections and inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11111735 on NIH RePORTER |
What this research studies
This research investigates how cellular stress, particularly in the endoplasmic reticulum (ER), influences the body's response to infections caused by Salmonella Typhimurium. It focuses on the role of specific receptors (NOD1 and NOD2) that detect bacterial components and trigger inflammatory responses. By examining the mechanisms of protein misfolding and calcium signaling during bacterial infections, the study aims to understand how these processes contribute to intestinal inflammation. The findings could lead to new insights into managing infections and inflammatory diseases of the gut.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with intestinal inflammatory diseases, particularly those related to bacterial infections.
Not a fit: Patients with non-infectious gastrointestinal disorders or those without any inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from intestinal inflammatory diseases caused by bacterial infections.
How similar studies have performed: Other research has shown promising results in understanding the link between cellular stress responses and bacterial infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Keestra-Gounder, Arina Marijke — University of Colorado Denver
- Study coordinator: Keestra-Gounder, Arina Marijke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.