How stress in cells affects infections from Salmonella bacteria
The impact of ER stress on Salmonella Typhimurium infections
This study is looking at how stress in our cells affects how our body fights off infections from Salmonella, and it aims to help people with intestinal inflammation by finding new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10876970 on NIH RePORTER |
What this research studies
This research investigates how cellular stress, particularly in the endoplasmic reticulum (ER), influences the body's response to infections caused by Salmonella Typhimurium. It focuses on the role of specific receptors (NOD1 and NOD2) that detect bacterial components and trigger inflammatory responses when the ER is under stress. By understanding these mechanisms, the research aims to uncover how inflammation in the intestines can be linked to bacterial infections and cellular dysfunction. Patients may benefit from insights that could lead to new treatments for intestinal inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with intestinal inflammatory diseases, particularly those related to bacterial infections.
Not a fit: Patients with non-infectious gastrointestinal disorders or those not experiencing intestinal inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from intestinal inflammatory diseases caused by bacterial infections.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular stress in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Keestra-Gounder, Arina Marijke — University of Colorado Denver
- Study coordinator: Keestra-Gounder, Arina Marijke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.