How stress in cells affects immune responses in bowel inflammation
Endoplasmic Reticulum Stress Controls Innate Lymphoid Cells in Intestinal Inflammation
['FUNDING_CAREER'] · WASHINGTON UNIVERSITY · NIH-11176049
This study is looking at how certain immune cells in your gut respond to stress and how that might help us find better, personalized treatments for people with inflammatory bowel disease (IBD).
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11176049 on ClinicalTrials.gov |
What this research studies
This research investigates the role of innate lymphoid cells in the development and management of inflammatory bowel disease (IBD). The study focuses on how endoplasmic reticulum stress influences these immune cells, which are crucial for gut health. By examining the interactions between immune cells and gut tissue, the research aims to uncover new insights that could lead to personalized treatment strategies for patients with IBD. The approach combines laboratory experiments with clinical insights to better understand the disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including conditions like Crohn's disease and ulcerative colitis.
Not a fit: Patients with bowel inflammation caused by non-autoimmune factors or those without a diagnosis of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatments for patients suffering from inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding immune cell behavior in bowel diseases, indicating that this approach has potential for success.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAO, SIYAN — WASHINGTON UNIVERSITY
- Study coordinator: CAO, SIYAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections