How stress in cells affects immune responses in bowel inflammation
Official title: Endoplasmic Reticulum Stress Controls Innate Lymphoid Cells in Intestinal Inflammation
Funded at Washington University · NIH-11176049 · Data updated 2026-11-12
This study is looking at how certain immune cells in your gut respond to stress and how that might help us find better, personalized treatments for people with inflammatory bowel disease (IBD).
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $166,584 |
| NIH project number | 5K08DK140612-02 |
| Project ID | NIH-11176049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including conditions like Crohn's disease and ulcerative colitis.
✕Less likely to help
Patients with bowel inflammation caused by non-autoimmune factors or those without a diagnosis of inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of innate lymphoid cells in the development and management of inflammatory bowel disease (IBD). The study focuses on how endoplasmic reticulum stress influences these immune cells, which are crucial for gut health. By examining the interactions between immune cells and gut tissue, the research aims to uncover new insights that could lead to personalized treatment strategies for patients with IBD. The approach combines laboratory experiments with clinical insights to better understand the disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatments for patients suffering from inflammatory bowel disease.
How similar studies have gone: Previous research has shown promising results in understanding immune cell behavior in bowel diseases, indicating that this approach has potential for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Cao, Siyan — Washington University
- Study coordinator: Cao, Siyan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.