How stress affects heart health in childhood cancer survivors treated with doxorubicin
Psychosocial Stress Exacerbates Doxorubicin-induced Cardiovascular Aging
This study looks at how stress can make heart issues worse in kids who have been treated for cancer with a drug called doxorubicin, and it aims to find ways to help protect their heart health as they grow up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10811762 on NIH RePORTER |
What this research studies
This research investigates how psychosocial stress can worsen heart problems in children who have received doxorubicin, a common cancer treatment. Using a mouse model, the study examines the biological mechanisms behind this relationship and tests potential treatments to prevent heart damage. By understanding how stress interacts with cancer treatment, the research aims to identify ways to protect the heart health of childhood cancer survivors. Patients may benefit from insights that could lead to better management of their cardiovascular health post-treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are childhood cancer survivors who have been treated with doxorubicin and are experiencing psychosocial stress.
Not a fit: Patients who have not received doxorubicin or do not have a history of psychosocial stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing heart damage in childhood cancer survivors who experience stress.
How similar studies have performed: Previous studies have shown that psychosocial stress can impact cardiovascular health, but this specific approach using a mouse model to explore the mechanisms is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Zordoky, Beshay — University of Minnesota
- Study coordinator: Zordoky, Beshay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.