How stress affects brain cells and their connections.
Heterogeneous microglia activation mediates stress-induced changes in neural circuitry.
This study is looking at how a type of brain cell called microglia changes when we're under chronic stress, and it aims to find out how these changes might affect brain function, which could help us discover new treatments for stress-related brain disorders.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10741172 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, a type of brain cell, in how chronic stress alters neural circuits. It aims to understand the specific pathways activated in these cells during stress and how this leads to changes in brain function. By analyzing the genetic activity in brain cells and creating specialized mouse models, the study seeks to uncover the mechanisms behind stress-related neurological disorders. This could provide insights into potential new treatments targeting microglia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic stress or related neurological symptoms.
Not a fit: Patients with acute stress or those not experiencing neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for neurological disorders exacerbated by stress.
How similar studies have performed: Other research has shown promising results in understanding microglial activation in stress, indicating potential for success in this approach.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Bhat, Manzoor a. — University of Texas Hlth Science Center
- Study coordinator: Bhat, Manzoor a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.