How Staphylococcus aureus reacts to low zinc levels during infection
The Staphylococcus aureus response to nutrient zinc restriction during infection
This study looks at how a common bacteria called Staphylococcus aureus behaves when there isn't enough zinc available during infections, with the goal of finding new ways to fight antibiotic-resistant infections and help your immune system work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10761720 on NIH RePORTER |
What this research studies
This research investigates how the bacteria Staphylococcus aureus responds to limited zinc availability during infections. By understanding the role of nutrient metals, particularly zinc, in bacterial behavior, the study aims to explore new strategies for combating antibiotic-resistant infections. The researchers utilize advanced imaging technologies to observe how these bacteria behave in different environments within the body, particularly in abscesses. This approach could lead to innovative treatments that target the nutritional needs of bacteria to enhance immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by Staphylococcus aureus, particularly those with antibiotic-resistant strains.
Not a fit: Patients with infections caused by other types of bacteria or those who do not have Staphylococcus aureus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat infections caused by antibiotic-resistant bacteria.
How similar studies have performed: Other research has shown promise in targeting bacterial nutrient acquisition as a novel approach to treating infections, indicating potential success for this study.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Skaar, Eric P — Vanderbilt University Medical Center
- Study coordinator: Skaar, Eric P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.