How specific proteins control cell growth and development in the brain
Protocadherin control of cell proliferation and differentiation
This study is looking at how certain proteins in the brain help control the growth and development of brain cells, using zebrafish to see how these proteins affect cell behavior, which could help us understand conditions like autism and epilepsy better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10821366 on NIH RePORTER |
What this research studies
This research investigates the role of a group of proteins called δ-pcdhs in regulating the growth and differentiation of brain cells during development. By studying zebrafish models, the researchers aim to understand how these proteins influence cell division and communication among cells in the brain. The approach includes observing changes in cell behavior and signaling pathways that may lead to developmental disorders or cancers. The findings could provide insights into how misregulation of these proteins contributes to conditions like autism and epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders such as autism or epilepsy, as well as those affected by specific cancers linked to cell proliferation issues.
Not a fit: Patients with conditions unrelated to neurodevelopmental disorders or cancers may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodevelopmental disorders and certain types of cancers.
How similar studies have performed: Previous research has shown that understanding cell adhesion molecules can lead to significant advancements in treating developmental disorders and cancers, indicating a promising avenue for this study.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Jontes, James David — Ohio State University
- Study coordinator: Jontes, James David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.