How specific brain pathways affect emotional memory and protein synthesis
Official title: Prefrontal pathway-specific modulation of protein synthesis in emotional memories
Funded at State University New York Stony Brook · NIH-10997369 · Data updated 2026-11-12
This study is looking at how specific brain pathways help us remember emotional experiences, especially when we feel threatened, and it aims to find new ways to help people with conditions like PTSD by understanding how these memories are formed and kept.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | December 8, 2023 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $484,084 |
| NIH project number | 5R01MH132795-02 |
| Project ID | NIH-10997369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced trauma and may be suffering from PTSD or related emotional memory issues.
✕Less likely to help
Patients who do not have a history of trauma or emotional memory disorders may not benefit from this research.
What this research studies
This research investigates how certain brain pathways influence the formation and consolidation of emotional memories, particularly in response to threats. By studying the mechanisms of protein synthesis in these pathways, the research aims to uncover how emotional memories are formed and maintained. The approach involves using animal models to simulate conditions similar to post-traumatic stress disorder (PTSD), focusing on how different intensities of threats and the ability to control these threats affect memory processes. The findings could lead to targeted therapies for individuals struggling with emotional memory disorders.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies for patients with PTSD and other emotional memory disorders.
How similar studies have gone: Previous research has shown promising results in understanding the neurobiological mechanisms of emotional memory, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Shrestha, Prerana — State University New York Stony Brook
- Study coordinator: Shrestha, Prerana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.