How specific brain cells help build connections in the cerebral cortex
Subplate-dependent mechanisms of cortical circuit assembly
This study is looking at how special brain cells called subplate neurons help shape the connections in the brain during its development, which could help us understand brain disorders that happen when these connections don't form correctly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10896430 on NIH RePORTER |
What this research studies
This research investigates the role of subplate neurons in the development of the cerebral cortex, focusing on how these neurons guide the growth of axons and form essential connections. By using advanced genetic techniques, the study aims to uncover the mechanisms by which subplate neurons influence circuit assembly during brain development. The research will explore three key processes: pioneering axon growth, co-fasciculation with other axons, and providing a supportive environment through the extracellular matrix. Understanding these processes could lead to insights into brain disorders linked to improper circuit formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions affecting brain development, such as Coffin-Siris Syndrome, particularly those with mutations in the ARID1A gene.
Not a fit: Patients with fully developed brains and no genetic predisposition to brain circuit assembly disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain development and lead to new treatments for brain disorders associated with circuit assembly issues.
How similar studies have performed: Previous studies have shown promising results in understanding the role of subplate neurons in brain development, indicating that this approach has potential for significant findings.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Kwan, Kenneth Yu-Chung — University of Michigan at Ann Arbor
- Study coordinator: Kwan, Kenneth Yu-Chung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.