How specialized ribosomes affect muscular dystrophy
Official title: Contribution of ribosome specialization to the pathophysiology of muscular dystrophy
Funded at University of Kentucky · NIH-11010392 · Data updated 2026-11-12
This study is looking at how a protein called RLP3L affects muscle health and could help us understand muscular dystrophy better, with the hope of finding new treatments that might improve the lives of people living with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | November 1, 2023 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $238,764 |
| NIH project number | 5R00AR081367-04 |
| Project ID | NIH-11010392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with muscular dystrophy, particularly those experiencing muscle functional decline.
✕Less likely to help
Patients with muscular dystrophy who are not experiencing significant muscle decline or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of a specific ribosomal protein, RLP3L, in muscle tissue and its impact on muscular dystrophy. The study aims to understand how the loss of RLP3L affects ribosome function and contributes to muscle decline in patients with muscular dystrophy. By examining the relationship between ribosome specialization and mitochondrial function, the research seeks to uncover new insights into disease progression and potential therapeutic targets. Patients may benefit from findings that could lead to innovative treatments for muscular dystrophy.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve muscle function and quality of life for patients with muscular dystrophy.
How similar studies have gone: While the specific approach of investigating ribosome specialization in muscular dystrophy is novel, related research has shown promising results in understanding ribosome function in other muscle-related conditions.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Wen, Yuan — University of Kentucky
- Study coordinator: Wen, Yuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.