How sleep affects learning and forgetting in the brain.
Official title: Role of coordinated multi-area reactivations during transitions between automatic and flexible behaviors.
Funded at University of California, San Francisco · NIH-10721280 · Data updated 2026-11-12
This study is looking at how sleep helps our brains learn and forget by watching brain activity in rats, which could help us understand how sleep affects our memory and behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,965,125 |
| NIH project number | 1RF1NS132913-01 |
| Project ID | NIH-10721280 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with psychiatric disorders or those experiencing difficulties with memory and behavior regulation.
✕Less likely to help
Patients with acute medical conditions unrelated to mental health or memory issues may not receive benefit from this research.
What this research studies
This research investigates the role of sleep in balancing learning and forgetting by examining neuronal activity during non-rapid-eye-movement sleep (NREMS). Using a rat model, the study will analyze how sleep influences the connections between different brain areas, particularly the cortex and striatum, and how this affects behavior. By employing advanced techniques like multi-site electrophysiology, the researchers aim to understand how these processes contribute to automatic versus flexible behaviors. The findings could provide insights into the underlying mechanisms of memory consolidation and behavioral regulation.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatments for mental health disorders related to memory and behavior.
How similar studies have gone: Previous research has shown promising results in understanding the role of sleep in memory processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Ganguly, Karunesh — University of California, San Francisco
- Study coordinator: Ganguly, Karunesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.