How sex differences affect brain signaling related to stress and anxiety in adolescents
Functional Implications of Sex Differences in Hippocampal Endocannabinoid Signaling
['FUNDING_R15'] · RAMAPO COLLEGE OF NEW JERSEY · NIH-10436407
This study looks at how natural brain chemicals called endocannabinoids affect learning, memory, and emotions in teenagers, especially focusing on why girls might be more prone to stress and anxiety than boys.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RAMAPO COLLEGE OF NEW JERSEY (nih funded) |
| Locations | 1 site (MAHWAH, UNITED STATES) |
| Trial ID | NIH-10436407 on ClinicalTrials.gov |
What this research studies
This research investigates how endocannabinoids, which are natural chemicals in the brain, influence behaviors like learning, memory, and emotional responses in adolescents. It focuses on understanding the differences between males and females in their endocannabinoid signaling, particularly in relation to stress and anxiety. By studying these differences, the research aims to uncover why females are more likely to develop stress-related disorders during adolescence. The approach includes examining brain receptor levels and their functional implications in both male and female subjects.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12-20, both male and female, who may be experiencing stress or anxiety-related issues.
Not a fit: Patients outside the age range of 12-20 or those not experiencing stress-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for stress-related disorders in adolescents, particularly for females who are at higher risk.
How similar studies have performed: Previous studies have indicated significant sex differences in endocannabinoid signaling, suggesting that this research could build on established findings, though the specific focus on adolescents is relatively novel.
Where this research is happening
MAHWAH, UNITED STATES
- RAMAPO COLLEGE OF NEW JERSEY — MAHWAH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REICH, CHRISTIAN G — RAMAPO COLLEGE OF NEW JERSEY
- Study coordinator: REICH, CHRISTIAN G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anxiety Disorders