How sex and salt intake affect hormone responses in the body
Official title: Aldosterone/mineralocorticoid receptor responses to biologic sex and salt intake: Role of Lysine Specific Demethylase 1 (LSD1)
Funded at Brigham and Women's Hospital · NIH-10930190 · Data updated 2026-11-12
This study is looking at how salt intake and whether someone is male or female can affect a hormone called aldosterone, which is important for people with high blood pressure, and it hopes to find new ways to tailor treatments for those dealing with related health problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 24, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $833,802 |
| NIH project number | 1R56HL166263-01A1 |
| Project ID | NIH-10930190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with mild hypertension or those experiencing symptoms related to aldosterone dysregulation.
✕Less likely to help
Patients with no history of hypertension or related chronic diseases may not benefit from this research.
What this research studies
This research investigates how aldosterone and its receptor are influenced by biological sex and salt consumption, particularly in relation to chronic diseases like hypertension. The study aims to understand the mechanisms behind aldosterone dysregulation, which may affect a significant portion of the population, including those with mild hypertension. By focusing on the role of an enzyme called Lysine Specific Demethylase 1 (LSD1), the research seeks to uncover how this enzyme regulates hormone expression in different dietary and biological contexts. This could lead to more personalized treatment approaches for patients suffering from related health issues.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized therapies for patients with hormone-related chronic diseases.
How similar studies have gone: Previous research has shown promising results in understanding hormone regulation, but this specific approach focusing on LSD1 and its interaction with sex and salt intake is relatively novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Pojoga, Luminita — Brigham and Women's Hospital
- Study coordinator: Pojoga, Luminita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.