How sex and leptin affect blood vessel function in Type 1 Diabetes
Official title: Sex and Leptin control of endothelial cell glycolysis and redox balance in Type 1 Diabetes
Funded at Augusta University · NIH-11103146 · Data updated 2026-11-12
This study is looking at how certain cells in your blood vessels work and how they are affected by factors like sex and a hormone called leptin in people with Type 1 Diabetes, with the goal of finding ways to keep your heart and blood vessels healthier.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | June 5, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $515,900 |
| NIH project number | 5P01HL160557-02 |
| Project ID | NIH-11103146 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 Diabetes, particularly women who may experience unique challenges related to endothelial function.
✕Less likely to help
Patients without Type 1 Diabetes or those with other forms of diabetes may not benefit from this research.
What this research studies
This research investigates the role of endothelial cells in regulating blood vessel function, particularly focusing on how glycolysis and redox balance are influenced by sex and leptin in patients with Type 1 Diabetes (T1D). The study aims to understand the molecular mechanisms that lead to endothelial dysfunction, a significant contributor to cardiovascular complications in T1D. By examining the effects of increased glycolytic activity and reactive oxygen species in endothelial cells, the research seeks to identify potential therapeutic targets to improve vascular health. The findings could lead to better management strategies for preventing cardiovascular events in T1D patients, especially in women who are often underrepresented in such studies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for preventing cardiovascular complications in patients with Type 1 Diabetes.
How similar studies have gone: Other research has shown promising results in understanding endothelial dysfunction in diabetes, but this specific focus on sex differences and leptin signaling is relatively novel.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Belin de Chantemele, Eric J — Augusta University
- Study coordinator: Belin de Chantemele, Eric J
Related research
Other NIH-funded projects on the same topics.
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Sex, leptin, and endothelial energy in Type 1 Diabetes
This grant studies how the energy use in the lining of blood vessels and the hormone leptin affect blood vessel health in people with Type 1 diabetes.
-
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.