How sex and gender affect disease progression from early development
The impact of sex and gender on disease progression, from developmental origins
This study looks at how hormonal and immune changes in early pregnancy might affect health later on, especially how these factors could lead to different disease risks for boys and girls, helping patients understand how their gender can influence their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10910890 on NIH RePORTER |
What this research studies
This research investigates how hormonal and immunological differences during the first trimester of pregnancy can influence the development of diseases later in life. By examining gene expression in the placenta, the study aims to identify how these differences may lead to varying disease outcomes between males and females. The research focuses on specific hormones and signaling pathways that could play a role in the development of autoimmune diseases and other health conditions. Patients may benefit from a better understanding of how their sex and gender influence their health risks and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of autoimmune diseases or those interested in understanding how early developmental factors may affect their health.
Not a fit: Patients who are not affected by autoimmune diseases or do not have a history of relevant health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies based on sex and gender differences in disease progression.
How similar studies have performed: Other research has shown success in understanding the impact of sex and gender on disease outcomes, making this approach both relevant and promising.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Pisarska, Margareta — Cedars-Sinai Medical Center
- Study coordinator: Pisarska, Margareta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.