How SETDB2 affects the development of abdominal aortic aneurysms
Official title: SETDB2 regulates Abdominal Aortic Aneurysms
Funded at University of Michigan at Ann Arbor · NIH-10873676 · Data updated 2026-11-12
This study is looking at how a protein called SETDB2 and immune cells called macrophages affect the development of abdominal aortic aneurysms (AAA), with the goal of finding new ways to prevent or treat this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $83,392 |
| NIH project number | 5F32HL167534-02 |
| Project ID | NIH-10873676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for abdominal aortic aneurysms, particularly those with a family history or other risk factors.
✕Less likely to help
Patients who do not have abdominal aortic aneurysms or are not at risk for developing them may not benefit from this research.
What this research studies
This research investigates the role of SETDB2, a specific protein, in the formation of abdominal aortic aneurysms (AAA). It focuses on how macrophages, a type of immune cell, contribute to the remodeling of blood vessels during AAA development. The study aims to understand the balance between proteins that break down the aortic wall and those that protect it, particularly in the context of epigenetic changes. By exploring the signaling pathways involved, the research seeks to uncover potential therapeutic targets for preventing or treating AAA.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the formation of abdominal aortic aneurysms, potentially saving lives.
How similar studies have gone: Previous research has shown success in understanding the role of macrophages in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Bauer, Tyler Michael — University of Michigan at Ann Arbor
- Study coordinator: Bauer, Tyler Michael
Related research
Other NIH-funded projects on the same topics.
-
Expanding genetic testing for cancer risk in patients and families
This study is working to make it easier for cancer patients in Michigan to get genetic testing for cancer risk by improving how doctors gather family history and assess genetic risks, so that more people can receive the important evaluations they need.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Why the retina can sometimes heal itself and how we might help it heal
This NIH grant explores how inflammation and neural cells interact in the zebrafish retina to understand retinal neuron death and regeneration, with potential implications for human vision.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Understanding how work exposures and genes influence ALS risk
A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.