How SETDB2 affects the development of abdominal aortic aneurysms
SETDB2 regulates Abdominal Aortic Aneurysms
This study is looking at how a protein called SETDB2 and immune cells called macrophages affect the development of abdominal aortic aneurysms (AAA), with the goal of finding new ways to prevent or treat this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10873676 on NIH RePORTER |
What this research studies
This research investigates the role of SETDB2, a specific protein, in the formation of abdominal aortic aneurysms (AAA). It focuses on how macrophages, a type of immune cell, contribute to the remodeling of blood vessels during AAA development. The study aims to understand the balance between proteins that break down the aortic wall and those that protect it, particularly in the context of epigenetic changes. By exploring the signaling pathways involved, the research seeks to uncover potential therapeutic targets for preventing or treating AAA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for abdominal aortic aneurysms, particularly those with a family history or other risk factors.
Not a fit: Patients who do not have abdominal aortic aneurysms or are not at risk for developing them may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the formation of abdominal aortic aneurysms, potentially saving lives.
How similar studies have performed: Previous research has shown success in understanding the role of macrophages in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Bauer, Tyler Michael — University of Michigan at Ann Arbor
- Study coordinator: Bauer, Tyler Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.