How serotonin affects mental effort during stress
Official title: Neurocomputational mechanisms of serotonin, sustained stress, and mental effort allocation
Funded at Brown University · NIH-10984600 · Data updated 2026-11-12
This study is looking at how serotonin affects how we manage our mental energy when we're under stress, helping us understand how our brains work in tough situations, which could be useful for anyone dealing with stress in their daily lives.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $114,899 |
| NIH project number | 1K99MH133912-01A1 |
| Project ID | NIH-10984600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic stress or anxiety, particularly those with cognitive control challenges.
✕Less likely to help
Patients who do not experience stress-related cognitive issues or those with severe neurological impairments may not benefit from this research.
What this research studies
This research investigates how serotonin influences the way people allocate their mental effort when faced with sustained stress. It aims to understand the neurocomputational mechanisms behind cognitive control, particularly in situations where stress is ongoing and potentially uncontrollable. By using a combination of psychopharmacology and advanced brain imaging techniques, the study will explore how individuals adjust their focus and responses under stress. This could provide insights into the cognitive processes that affect productivity and well-being.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for managing stress and improving cognitive performance in challenging situations.
How similar studies have gone: Previous research has shown promising results in understanding the role of serotonin in stress and cognitive control, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Yee, Debbie — Brown University
- Study coordinator: Yee, Debbie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.