How Salmonella bacteria manage drug resistance and virulence
Coordinate Regulation of Salmonella Virulence and Antimicrobial Resistance by MarR Transcription Factors
This study is looking at how Salmonella bacteria manage to resist antibiotics and cause illness, focusing on certain proteins that help them respond to their environment, with the goal of finding new ways to fight infections that are hard to treat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10848287 on NIH RePORTER |
What this research studies
This research investigates how Salmonella bacteria regulate their ability to resist antibiotics and cause disease. It focuses on specific proteins called MarR and SlyA, which help control the expression of genes related to drug resistance and virulence in response to metabolic signals. By identifying the molecules that interact with these proteins, the research aims to understand the connection between bacterial metabolism, resistance to antibiotics, and the ability to cause infections. This could lead to new strategies for combating antibiotic-resistant infections.
Who could benefit from this research
Good fit: Patients suffering from infections caused by Salmonella or other antibiotic-resistant bacteria would be ideal candidates to benefit from this research.
Not a fit: Patients with infections caused by non-bacterial pathogens or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat antibiotic-resistant Salmonella infections.
How similar studies have performed: Other research has shown promising results in understanding bacterial resistance mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Fang, Ferric C — University of Washington
- Study coordinator: Fang, Ferric C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.