How RNA binding proteins control how genes are expressed
Official title: How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changes
Funded at Columbia Univ New York Morningside · NIH-11392329 · Data updated 2026-11-12
This grant aims to map how RNA binding proteins influence when and how genes are turned on or off in disease, helping us understand post-transcriptional gene regulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $404,009 |
| NIH project number | 5R35GM152258-03 |
| Project ID | NIH-11392329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable here because the study is fundamental biology; patient involvement may occur later if findings translate to disease.
✕Less likely to help
This project is primarily laboratory research and does not involve direct patient participation.
What this research studies
Researchers will study more than 2,000 RNA binding proteins to see how they interact with RNAs and with each other during normal biology and disease. They will develop methods to measure many protein-RNA interactions in parallel, so we can see how networks change over time and in disease states. The goal is to connect these molecular interactions to real-world disease processes and identify potential points for intervention.
Why it matters
Potential benefit: If successful, this work could reveal new targets for therapies that correct gene expression problems at the RNA level in diseases.
How similar studies have gone: Previous studies have shown that RNA binding proteins regulate many RNA processes, supporting the potential of this approach.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Jovanovic, Marko — Columbia Univ New York Morningside
- Study coordinator: Jovanovic, Marko
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.