How RNA and proteins regulate antiviral signaling in the body
Official title: Regulation of the MAVS Signalosome by RNA and RNA-binding Proteins
Funded at University of Washington · NIH-10875623 · Data updated 2026-11-12
This study is looking at how certain molecules in our body help fight off viruses, which could lead to better treatments for viral infections and autoimmune diseases that affect people like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $127,926 |
| NIH project number | 5K99AI175483-02 |
| Project ID | NIH-10875623 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or those affected by viral infections.
✕Less likely to help
Patients with non-viral related conditions or those not affected by autoimmune diseases may not receive benefit from this research.
What this research studies
This research investigates the role of RNA and RNA-binding proteins in the MAVS signalosome, which is crucial for the body's antiviral immune response. By examining how these components interact and influence signaling pathways, the research aims to uncover new mechanisms that could enhance our understanding of immune responses to viral infections. The approach includes biochemical methods, sequencing, and proteomic techniques to analyze these interactions in detail. Patients may benefit from insights gained that could lead to improved treatments for viral infections and autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing antiviral immunity and managing autoimmune diseases.
How similar studies have gone: Other research has shown promising results in understanding RNA's role in immune signaling, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Gokhale, Nandan Satish — University of Washington
- Study coordinator: Gokhale, Nandan Satish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.