How regulatory T cells help keep the immune system balanced
Official title: Regulatory T cells maintain immune homeostasis through translation control
Funded at Benaroya Research Inst at Virginia Mason · NIH-11000858 · Data updated 2026-11-12
This study is looking at how certain immune cells, called regulatory T cells, help keep your immune system balanced and prevent it from mistakenly attacking your own body, which could lead to conditions like type 1 diabetes and multiple sclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | December 13, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $831,400 |
| NIH project number | 5R01AI181275-02 |
| Project ID | NIH-11000858 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases such as type 1 diabetes or multiple sclerosis.
✕Less likely to help
Patients with non-autoimmune conditions or those without any immune system disorders may not benefit from this research.
What this research studies
This research investigates the role of regulatory T cells in maintaining a balanced immune system and preventing autoimmune diseases. It focuses on understanding how these specialized cells suppress the activity of other immune cells that can cause harm when they mistakenly attack the body's own tissues. By examining the mechanisms of this suppression, the research aims to uncover new insights into how immune tolerance is achieved and maintained. This could lead to better strategies for treating autoimmune conditions like type 1 diabetes and multiple sclerosis.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance immune tolerance and prevent or treat autoimmune diseases.
How similar studies have gone: Previous research has shown that understanding the mechanisms of regulatory T cells can lead to significant advancements in treating autoimmune diseases, indicating that this approach has potential for success.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Ziegler, Steven F — Benaroya Research Inst at Virginia Mason
- Study coordinator: Ziegler, Steven F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.